Related Experiment Video
Updated: Jun 27, 2026
03:23
Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
Published on: May 10, 2024
Temporal arteritis in a patient with eosinophilia.
R Querubin1, M Abubaker, B Koplan
1Division of Rheumatology.
Summary
This case study highlights eosinophilic temporal arteritis, a rare condition. Eosinophilia should not prevent considering temporal artery biopsy for suspected temporal arteritis.
Area of Science:
- Rheumatology
- Neurology
- Pathology
Background:
- Temporal arteritis (TA), a large vessel vasculitis, typically presents with non-specific symptoms.
- Peripheral eosinophilia is an uncommon finding in TA, with few reported cases linked to specific comorbidities.
- This report details a unique instance of eosinophilic TA without associated conditions.
Purpose of the Study:
- To report a rare case of eosinophilic temporal arteritis.
- To emphasize the diagnostic importance of temporal artery biopsy in suspected TA, even with eosinophilia.
- To contribute to the limited literature on eosinophilic TA.
Main Methods:
- Case presentation of a 69-year-old male with prolonged fever and headache.
- Diagnostic workup including temporal artery biopsy.
- Therapeutic trial with corticosteroids.
Main Results:
- Temporal artery biopsy revealed transmural inflammation with eosinophilia.
- Corticosteroid therapy led to resolution of symptoms and normalization of inflammatory markers.
- The patient's condition was diagnosed as eosinophilic temporal arteritis without known associated conditions.
Conclusions:
- Eosinophilic temporal arteritis can occur in the absence of juvenile TA, AIDS, or Buerger's disease.
- Physicians should maintain a high index of suspicion for TA in patients with suggestive symptoms, regardless of peripheral eosinophilia.
- Temporal artery biopsy remains a crucial diagnostic tool for TA.
Related Concept Videos
01:28Asthma I: Introduction
Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
01:13Asthma III: Clinical Manifestations
Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
01:30Asthma-IV: Diagnostic and Management
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
01:26Asthma-II: Pathophysiology and Classification
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
01:20Asthma: Pathogenesis and Management
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.