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Related Experiment Video

Updated: Jun 27, 2026

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
09:39

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

Published on: February 13, 2018

Multifocal small fiber sensory neuropathy.

D Lacomis1, K E Tobin, M J Giuliani

  • 1From the Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh. PA.

Journal of Clinical Neuromuscular Disease
|December 17, 2008
PubMed
Summary
This summary is machine-generated.

Unusual multifocal small fiber sensory neuropathies can occur after infections. Objective testing of small fiber function is crucial for diagnosis in these postinfectious cases.

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Last Updated: Jun 27, 2026

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
09:39

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Published on: February 13, 2018

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Corneal Confocal Microscopy: A Novel Non-invasive Technique to Quantify Small Fibre Pathology in Peripheral Neuropathies
11:29

Corneal Confocal Microscopy: A Novel Non-invasive Technique to Quantify Small Fibre Pathology in Peripheral Neuropathies

Published on: January 3, 2011

Area of Science:

  • Neurology
  • Neuroscience

Background:

  • Small fiber sensory neuropathy (SFN) typically presents with distal sensory symptoms.
  • Postinfectious neuropathies are a known clinical entity.
  • Unusual presentations of SFN require further investigation.

Purpose of the Study:

  • To describe four patients with atypical multifocal SFN.
  • To highlight the diagnostic utility of objective small fiber testing.

Main Methods:

  • Four patients with postinfectious sensory symptoms were evaluated.
  • Neurologic examinations, nerve conduction studies, and serologic tests were performed.
  • Small nerve fiber function was assessed using thermal/vibratory thresholds, quantitative sudomotor axon reflex testing (QSART), and autonomic cardiovascular testing.

Main Results:

  • Standard nerve conduction and serologic studies were unremarkable.
  • QSART and/or autonomic testing revealed small fiber dysfunction in all patients.
  • One patient had abnormal thermal thresholds; three experienced fluctuating symptoms.

Conclusions:

  • SFN can manifest multifocally, not just distally, as part of the postinfectious neuropathy spectrum.
  • Objective testing of small fiber function is essential for diagnosing SFN in this context.
  • Early identification aids in distinguishing SFN from other causes of paresthesia.