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Related Concept Videos

Diabetic Neuropathy01:22

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Leishmaniasis01:30

Leishmaniasis

Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...
Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

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Related Experiment Video

Updated: Jun 27, 2026

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
09:39

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

Published on: February 13, 2018

Lepromatous neuropathy.

D J Altman1, A Amato

  • 1From the *Department of Medicine/Neurology, University of Texas health Sciences at San Antoins,and the daggerDepartment of Neurology Brigham and Women's Hospital, Boston, MA.

Journal of Clinical Neuromuscular Disease
|December 17, 2008
PubMed
Summary
This summary is machine-generated.

Leprosy causes peripheral neuropathy, affecting nerves in limbs. Treatment involves long-term antibiotics, but reversal reactions can worsen symptoms, requiring neurologist awareness.

Related Experiment Videos

Last Updated: Jun 27, 2026

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
09:39

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

Published on: February 13, 2018

Area of Science:

  • Neurology
  • Infectious Diseases

Background:

  • Leprosy is a significant cause of peripheral neuropathy globally, especially in endemic regions.
  • Neuropathy in leprosy presents diversely, including mononeuropathies and generalized sensorimotor polyneuropathy.

Purpose of the Study:

  • To highlight the complex clinical manifestations, pathogenesis, and treatment of lepromatous neuropathy.
  • To increase neurologist awareness of this condition.

Main Methods:

  • Electrophysiologic studies were used to characterize the neuropathy.
  • Clinical observations of treatment and complications were analyzed.

Main Results:

  • Electrophysiology indicates a primary axonal process, with possible demyelinating features.
  • Long-term multidrug therapy (dapsone, rifampin, clofazimine) is standard.
  • Reversal reactions, an immune-mediated complication, can exacerbate skin lesions and neuropathy.

Conclusions:

  • Lepromatous neuropathy is a common complication requiring comprehensive understanding.
  • Neurologists must be aware of leprosy's varied presentations and treatment challenges, including immune reactions.