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ALS - Motor Neuron Disease: Mechanism and Development of New Therapies

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies

Published on: July 29, 2007

Post-radiation lower motor neuron syndrome.

R W van der Sluis¹, G I Wolfe, S P Nations

¹From the *Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, and the daggerDepartment of Neurology, Ohio State University School of Medicine, Columbus, Ohio.

Journal of Clinical Neuromuscular Disease

|December 17, 2008

Summary

This summary is machine-generated.

Post-radiation lower motor neuron syndrome (PRLMNS) presents with weakness and muscle atrophy in areas exposed to radiation. This condition has a more favorable prognosis than amyotrophic lateral sclerosis.

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Area of Science:

Neurology
Oncology
Radiology

Background:

Post-radiation lower motor neuron syndrome (PRLMNS) is a known complication of radiation therapy for malignancies.
Descriptions of PRLMNS date back to World War II.

Purpose of the Study:

To describe the clinical features of four patients with PRLMNS.
To review the existing literature on PRLMNS.

Main Methods:

Evaluation of four patients who developed lower motor neuron syndrome after radiation therapy.
Description of clinical and electrophysiological features.

Main Results:

Patients exhibited weakness, atrophy, and fasciculations in radiation-exposed areas, with a mean onset of 14 years post-radiation.
Electromyography revealed denervation changes; MRI and myelography were unremarkable.
The condition showed a stable to slowly progressive course over a mean follow-up of 6.5 years.

Conclusions:

Clinicians should inquire about prior radiation exposure in patients with lower motor neuron syndromes.
PRLMNS offers a relatively favorable prognosis compared to amyotrophic lateral sclerosis.