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Randomised phase II study of ASA404 combined with carboplatin and paclitaxel in previously untreated advanced
M J McKeage1, J Von Pawel, M Reck
1University of Auckland, 85 Park Road, Grafton, Private Bag 92019, Auckland 1142, New Zealand.
British Journal of Cancer
|December 17, 2008
Abstract:
ASA404 (5,6-dimethylxanthenone-4-acetic acid or DMXAA) is a small-molecule tumour-vascular disrupting agent (Tumour-VDA). This randomised phase II study evaluated ASA404 plus standard therapy of carboplatin and paclitaxel in patients with histologically confirmed stage IIIb or IV non-small cell lung cancer (NSCLC) not previously treated with chemotherapy. Patients were randomised to receive