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Related Concept Videos

Active versus Passive Immunity01:31

Active versus Passive Immunity

Immunity, along with the ability to limit pathogen growth to prevent significant body tissue damage, can be gained either by (1) actively developing an immune response within the individual after exposure to a pathogen or after getting vaccinated or (2) passively transferring immune components from an immune individual to one who is nonimmune. Both these forms of immunity can be found naturally and in medical practices.
Active Immunity
Active immunity refers to the resistance one develops...
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Introduction to Innate and Adaptive Immunity01:21

Introduction to Innate and Adaptive Immunity

The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...

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Related Experiment Video

Updated: Jun 27, 2026

Sexual Transmission of American Trypanosomes from Males and Females to Naive Mates
13:55

Sexual Transmission of American Trypanosomes from Males and Females to Naive Mates

Published on: January 27, 2019

Immune privilege or privileged immunity?

J V Forrester1, H Xu, T Lambe

  • 1Department of Ophthalmology, University of Aberdeen, Aberdeen, Scotland. j.forrester@abdn.ac.uk

Mucosal Immunology
|December 17, 2008
PubMed
Summary

Immune privilege, once passive, is now understood as active mechanisms contributing to self-antigen non-reactivity. This tissue-specific phenomenon offers new therapeutic strategies for tumors and organ transplantation.

Area of Science:

  • Immunology
  • Transplantation Biology
  • Tissue Engineering

Background:

  • Immune privilege was historically viewed as a passive state limited to specific tissues.
  • Emerging research reveals immune privilege involves active and passive mechanisms, overlapping with peripheral tolerance.

Purpose of the Study:

  • To re-evaluate the concept of immune privilege.
  • To propose a novel framework for understanding immune privilege as a third route to immunological tolerance.
  • To highlight the therapeutic potential of manipulating immune privilege.

Main Methods:

  • Conceptual review and synthesis of existing literature on immune privilege and tolerance.
  • Analysis of mechanisms contributing to tissue-specific immune privilege.
  • Exploration of therapeutic applications based on modulating immune privilege.

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Isolating Lymphocytes from the Mouse Small Intestinal Immune System

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Last Updated: Jun 27, 2026

Sexual Transmission of American Trypanosomes from Males and Females to Naive Mates
13:55

Sexual Transmission of American Trypanosomes from Males and Females to Naive Mates

Published on: January 27, 2019

Isolation of Lamina Propria Mononuclear Cells from Murine Colon Using Collagenase E
09:48

Isolation of Lamina Propria Mononuclear Cells from Murine Colon Using Collagenase E

Published on: September 26, 2019

Isolating Lymphocytes from the Mouse Small Intestinal Immune System
11:28

Isolating Lymphocytes from the Mouse Small Intestinal Immune System

Published on: February 28, 2018

Main Results:

  • Immune privilege is an active, multifaceted phenomenon with varying degrees across different tissues.
  • Immune privilege can be induced in non-privileged sites, indicating it's a property of the tissue.
  • A third route to immunological tolerance is proposed, centered on tissue-specific properties.

Conclusions:

  • Immune privilege represents a distinct mechanism of inducing immunological tolerance.
  • Understanding tissue-specific immune privilege can inform strategies for cancer immunotherapy by disrupting privilege.
  • Promoting immune privilege in specific tissues may enhance graft survival in transplantation.