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Updated: Jun 27, 2026

Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice
Published on: April 21, 2015
IKK/NF-kappaB signaling in intestinal epithelial cells controls immune homeostasis in the gut
1Institute for Genetics, University of Cologne, Cologne, Germany. pasparakis@uni-koeln.de
Abstract:
The intestinal epithelium regulates the interaction between commensal bacteria and the immune system not only by providing a physical barrier but also by expressing a number of immunoregulatory and antimicrobial peptides. Recent studies showed that inhibition of IkappaB kinase (IKK)/nuclear factor-kappaB (NF-kappaB) signaling specifically in intestinal epithelial cells in vivo causes the spontaneous development of intestinal inflammation in mice. These findings identify IKK/NF-kappaB signaling in intestinal epithelial cells as an important factor for the maintenance of epithelial integrity and immune homeostasis in the gut.
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