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Updated: Jun 27, 2026

Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation
Published on: August 21, 2019
Integrated network analysis platform for protein-protein interactions
Jianmin Wu1, Tea Vallenius, Kristian Ovaska
1Genome-Scale Biology Program, Institute of Biomedicine, University of Helsinki, Haartmaninkatu 8, Helsinki, Finland. jianmin.wu@helsinki.fi
Abstract:
There is an increasing demand for network analysis of protein-protein interactions (PPIs). We introduce a web-based protein interaction network analysis platform (PINA), which integrates PPI data from six databases and provides network construction, filtering, analysis and visualization tools. We demonstrated the advantages of PINA by analyzing two human PPI networks; our results suggested a link between LKB1 and TGFbeta signaling, and revealed possible competitive interactors of p53 and c-Jun.
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