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A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

Autophagy genes and ageing.

¹Department of Genetics, Eötvös Loránd University, Budapest H-1117, Hungary. vellai@falco.elte.hu

Cell Death and Differentiation

|December 17, 2008

Summary

Autophagy, a cellular self-eating process, is crucial for aging control. Enhancing autophagy gene expression can extend lifespan and slow tissue aging across diverse organisms.

Area of Science:

Cellular Biology
Gerontology
Genetics

Background:

Aging is a multifactorial process influenced by conserved pathways, mitochondrial function, and environmental factors.
Intracellular accumulation of damaged proteins and mitochondria is a hallmark of aged cells.
Autophagy (cellular self-eating) is a key process for degrading cellular waste and damaged components.

Purpose of the Study:

To review the molecular mechanisms linking autophagy genes with longevity pathways.
To explore the role of autophagy in regulating the aging process across diverse species.

Main Methods:

Review of genetic studies in model organisms (nematodes, flies).
Analysis of conserved signaling pathways and their interaction with autophagy.

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A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

Assessing Lysosomal Alkalinization in the Intestine of Live Caenorhabditis elegans

Assessing Lysosomal Alkalinization in the Intestine of Live Caenorhabditis elegans

Published on: April 13, 2018

In Situ Immunofluorescent Staining of Autophagy in Muscle Stem Cells

In Situ Immunofluorescent Staining of Autophagy in Muscle Stem Cells

Published on: June 12, 2017

Examination of environmental factors influencing aging and autophagy.

Main Results:

Autophagy-related genes are essential for lifespan extension in long-lived mutants and survival during starvation.
Promoting basal autophagy gene (Atg8) expression in the nervous system of Drosophila extends lifespan by 50%.
Autophagy plays a conserved role in regulating the rate of tissue aging.

Conclusions:

Autophagy is a critical regulator of aging and longevity across a wide range of organisms.
Targeting autophagy pathways offers potential therapeutic strategies for age-related decline.