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Related Concept Videos

Forced Transdifferentiation01:28

Forced Transdifferentiation

Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial transdifferentiation occurs...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Cellular Differentiation00:57

Cellular Differentiation

How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

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Related Experiment Video

Updated: Jun 27, 2026

Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency
09:07

Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency

Published on: June 10, 2018

Stem cells, phenotypic inversion, and differentiation.

Robert W Siggins, Ping Zhang, David Welsh

    International Journal of Clinical and Experimental Medicine
    |December 17, 2008
    PubMed
    Summary
    This summary is machine-generated.

    Stem cell therapies face challenges due to low cell numbers. Discovering stem/progenitor cell inversion offers a new method to generate sufficient stem cells for treating diseases.

    Keywords:
    Stem cellsdifferentiationinversionmicrotubulesmitochondria

    More Related Videos

    In Vitro Differentiation of Human Pluripotent Stem Cells into Trophoblastic Cells
    08:21

    In Vitro Differentiation of Human Pluripotent Stem Cells into Trophoblastic Cells

    Published on: March 16, 2017

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    Last Updated: Jun 27, 2026

    Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency
    09:07

    Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency

    Published on: June 10, 2018

    In Vitro Differentiation of Human Pluripotent Stem Cells into Trophoblastic Cells
    08:21

    In Vitro Differentiation of Human Pluripotent Stem Cells into Trophoblastic Cells

    Published on: March 16, 2017

    Area of Science:

    • Regenerative Medicine
    • Cell Biology
    • Biotechnology

    Background:

    • Stem cells hold promise for treating diverse diseases, from congenital conditions to age-related illnesses.
    • Adult stem cells are rare and difficult to isolate in sufficient quantities for therapeutic use, necessitating ex vivo expansion.
    • Current limitations in stem cell availability hinder widespread clinical application.

    Purpose of the Study:

    • To explore the potential of stem/progenitor cell inversion as a novel strategy for generating adequate stem cell numbers.
    • To investigate the role of mitochondrial biogenesis and the microtubule cytoskeleton in stem cell differentiation and phenotypic inversion.
    • To identify new avenues for advancing stem cell-based therapies.

    Main Methods:

    • Investigating the concept of stem/progenitor cell inversion.
    • Analyzing the characteristics of adult progenitor cells versus quiescent stem cells.
    • Examining the relationship between mitochondrial biogenesis, microtubule cytoskeleton, and stem cell differentiation.
    • Exploring methods to induce phenotypic inversion for therapeutic purposes.

    Main Results:

    • Adult progenitor cells are more abundant and easier to isolate than quiescent stem cells.
    • Stem/progenitor cell inversion presents a potential method for increasing stem cell yield.
    • Mitochondrial biogenesis, regulated by the microtubule cytoskeleton, is crucial for stem cell differentiation.

    Conclusions:

    • Stem/progenitor cell inversion may offer a feasible approach to obtain sufficient stem cells for therapeutic applications.
    • Understanding and manipulating mitochondrial biogenesis could be key to controlling cell differentiation and inducing phenotypic inversion.
    • Further research in these areas could significantly contribute to the development of effective stem cell-based treatments.