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The compositional properties of human genes.

B Aïssani1, G D'Onofrio, D Mouchiroud

  • 1Laboratoire de Génétique Moléculaire, Institut Jacques Monod, Paris, France.

Journal of Molecular Evolution
|June 1, 1991
PubMed
Summary

This study reveals compositional correlations between human gene exons and their associated noncoding DNA (introns and intergenic sequences) within the same isochores. These findings confirm that coding and noncoding DNA share similar GC levels.

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Area of Science:

  • Genomics
  • Molecular Biology
  • Bioinformatics

Background:

  • Previous research suggested compositional correlations in genomes.
  • Gene localization and flanking sequences provide additional data for analysis.

Purpose of the Study:

  • To investigate compositional correlations between human gene exons and associated noncoding sequences (intergenic regions and introns).
  • To examine GC level relationships within different genomic regions and codon positions.

Main Methods:

  • Analysis of gene localization data and extended flanking sequences from gene banks.
  • Statistical analysis of GC levels in exons, introns, and intergenic sequences.
  • Investigation of correlations between codon positions and associated noncoding sequences.

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Main Results:

  • Linear relationships with slopes near unity were observed between GC levels of exons and their associated intergenic sequences or introns.
  • Intergenic sequences and introns within the same isochores exhibit similar GC levels.
  • Both intergenic sequences and introns showed GC levels 5-10% lower than corresponding exons.
  • Linear correlations were found among GC levels of codon positions and associated noncoding sequences.

Conclusions:

  • Coding and noncoding sequences from the same genomic isochores are compositionally correlated.
  • The findings strengthen the evidence for compositional homogeneity within isochores.
  • GC levels of codon positions are also correlated with associated noncoding sequences and among themselves.