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Updated: Jun 27, 2026
Comparative Lesions Analysis Through a Targeted Sequencing Approach
Published on: November 5, 2019
[Clinical and pathological analysis of rare nonepithelial vulvar tumors]
Hui-mei Zhou1, Jing-he Lang, Lan Zhu
1Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
Objective:
To study the clinical presentation and pathological features of rare nonepithelial vulvar tumors.
Methods:
The clinical data of 42 patients with nonepithelial vulvar tumors who were operated on during 1986 to 2007 in Peking Union Medical College Hospital were analyzed.
Results:
The average age of 42 patients was 44.1 years. There were 32 cases (76%) with a vulvar mass. Twenty one of these 42 patients (50%) complained of associated symptoms of itch and pain. Surgical treatment was the chief treatment of nonepithelial vulvar tumors, which included local excision (40, 95%), simple vulvectomy (1, 2%) and radical vulvectomy (1, 2%). Among the pathological diagnoses after operation, the most common benign histological subtypes were hidradenoma and haemangioma, while the most common malignant histological subtypes were leiomyosarcoma and aggressive angiomyxoma.
Conclusions:
Most of the nonepithelial vulvar tumors are mesenchymal tumors. The clinical presentation has no special characteristics. Diagnosis of nonepithelial vulvar tumors can be made based on histological inspection. Surgical treatment is the treatment of choice.
