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Updated: Jun 27, 2026
Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
[Expression of cyclooxygenase-2 in bladder transitional cell carcinoma and the significance thereof]
Lei Yu1, Xiao-jiang Chen, Pei-qing Shi
1Department of Urology, First Hospital of Harbin, Harbin 150010, China. yuleidoctor@yahoo.com.cn
Objective:
To study the expression of cyclooxygenase-2 (COX-2) in bladder transitional cell carcinoma (Tcc) and the clinical significance thereof.
Methods:
Immunohistochemistry was used to detect the expression of COX-2 in 56 specimens of bladder Tcc and 10 specimens of normal bladder tissue, all resected during operation.
Results:
No expression of COX-2 was detected in the 10 specimens of normal bladder tissue and in the 56 specimens of bladder Tcc the positive rate of COX-2 was 55.36%. The expression of COX-2 in bladder Tcc was closely correlated with the grade and stage of tumor (both P < 0.01).
Conclusion:
COX-2 expression in bladder Tcc is closely correlated with the grade and stage.
