Clinical implications of low-penetrance breast cancer susceptibility alleles
Francis Freisinger1, Susan M Domchek
1Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA.
Abstract:
Our understanding of breast cancer genetics is evolving beyond deleterious mutations in BRCA1 and BRCA2. In the past several years, several low- and moderate-risk breast cancer susceptibility alleles have been identified that have a relative risk for breast cancer of < or = 2. The availability of new techniques such as genome-wide association studies ensures that more low-risk alleles will be identified. This article reviews our current understanding of low-penetrance genes, with a specific focus on their clinical implications.
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