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Updated: Jun 27, 2026

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
Published on: March 17, 2016
Management of complications from estrogen deprivation in breast cancer patients
Dawn L Hershman1, Christina Cho, Katherine D Crew
1Department of Medicine and Epidemiology, College of Physicians and Surgeons and the Mailman School of Public Health, New York Presbyterian Hospital, Columbia University Medical Center, New York, NY 10032, USA. dlh23@columbia.edu
Abstract:
In the United States today, more than 2 million women live as breast cancer survivors. As the number of cancer survivors grows, the unique long-term side effects of cancer treatment and aging play an increasingly prominent role in the routine care of these patients. Of special concern are the short- and long-term effects of sex hormone deprivation. This article reviews current issues surrounding the acute and late effects associated with hormone deprivation in breast cancer survivors and summarizes the scientific and therapeutic discoveries to date to identify optimal nonestrogenic treatments for symptom control in individual patients.
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