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[Migraine and interatrial septal abnormalities in patients under 55 with cryptogenic stroke]

Patricia Martínez-Sánchez1, Blanca Fuentes Gimeno, José María Oliver Ruiz

  • 1Unidad de Ictus, Servicio de Neurología, Hospital Universitario La Paz, Universidad Autónoma de Madrid, Madrid, España.

Medicina Clinica
|December 17, 2008
PubMed
Abstract

Insights

Migraine patients under 55 with cryptogenic stroke have a higher association with patent foramen ovale (PFO) and atrial septal aneurysm (ASA). This double interatrial septal abnormality is more common in women with PFO.

Area of Science:

  • Cardiology
  • Neurology
  • Genetics

Context:

  • Patent foramen ovale (PFO) is prevalent in migraine sufferers and a known cause of ischemic stroke in individuals under 55.
  • Cryptogenic strokes, particularly in younger populations, warrant investigation into potential underlying cardiac and vascular anomalies.

Purpose:

  • To investigate the association between patent foramen ovale (PFO) and migraine in patients under 55 experiencing their first ischemic stroke of unknown origin.
  • To analyze demographic data, vascular risk factors, stroke characteristics, and outcomes in relation to migraine history and PFO presence.

Summary:

  • This observational study included 130 first-ever ischemic stroke patients under 55 years old.
  • Migraine was reported by 13.8% of patients, with a significantly higher prevalence in females (27.8%).
  • A history of migraine was associated with a higher incidence of PFO plus atrial septal aneurysm (ASA), particularly in women.

Impact:

  • The findings suggest a potential link between migraine and specific interatrial septal abnormalities, such as PFO plus ASA, in young stroke patients.
  • This association may be more pronounced in women, highlighting a potential sex-specific risk factor for cryptogenic stroke in migraineurs.

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