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Updated: Jun 27, 2026
05:17
Fast and Specific Assessment of the Halogenating Peroxidase Activity in Leukocyte-enriched Blood Samples
Published on: July 28, 2016
Myeloperoxidase overexpression in children with hypercholesterolemia.
P Pignatelli1, L Loffredo, F Martino
1Division of Internal Medicine H, La Sapienza University of Rome, Italy. pasquale.pignatelli@uniroma1.it
Atherosclerosis
|December 17, 2008
Summary
Children with hypercholesterolemia exhibit early and persistent oxidative stress, indicated by elevated biomarkers. This suggests a potential role for myeloperoxidase in the condition, unlike in healthy children where oxidative stress decreases with age.
Area of Science:
- Pediatric Endocrinology
- Cardiovascular Research
- Biochemistry
Background:
- Oxidative stress biomarkers typically decrease with age in healthy children (1-11 years).
- Limited data exists on age-related oxidative stress in children with hypercholesterolemia.
Purpose of the Study:
- To investigate prolonged exposure to enhanced oxidative stress in hypercholesterolemic children.
- To elucidate the underlying mechanisms of oxidative stress in this population.
Main Methods:
- Cross-sectional study comparing 95 normocholesterolemic and 95 hypercholesterolemic children.
- Plasma levels of 8-hydroxy-2'deoxyguanosine, oxidized-LDL, and myeloperoxidase were measured.
Main Results:
- Hypercholesterolemic children showed higher levels of 8-hydroxy-2'deoxyguanosine, oxidized-LDL, and myeloperoxidase compared to controls.
- Total cholesterol correlated directly with these oxidative stress markers.
- Unlike normocholesterolemic children, hypercholesterolemic children displayed no significant age-related decrease in these markers across age quartiles.
Conclusions:
- Hypercholesterolemic children experience early and persistent oxidative stress.
- Myeloperoxidase up-regulation may contribute to the observed oxidative stress in these children.
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