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DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

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Updated: Jun 27, 2026

Colorectal Cancer Cell Surface Protein Profiling Using an Antibody Microarray and Fluorescence Multiplexing

Colorectal Cancer Cell Surface Protein Profiling Using an Antibody Microarray and Fluorescence Multiplexing

Published on: September 25, 2011

Gene expression profiling in colorectal cancer using microarray technologies: results and perspectives.

Margherita Nannini¹, Maria Abbondanza Pantaleo, Alessandra Maleddu

¹Department of Hematology and Oncology sciences "L. A. Seragnoli", Sant'Orsola-Malpighi Hospital, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy.

Cancer Treatment Reviews

|December 17, 2008

Summary

This summary is machine-generated.

Molecular biology and gene expression profiling using microarrays offer insights into colorectal cancer progression. This review examines current microarray applications and future directions for molecular classification and targeted therapies.

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Area of Science:

Molecular biology
Medical oncology
Cancer research

Background:

Molecular biology provides a detailed view of tumor progression and carcinogenesis.
Gene expression profiling with microarrays analyzes thousands of genes simultaneously.
Colorectal cancer research needs molecular classification and prognostic/predictive factors.

Purpose of the Study:

Review the current state of gene expression profiling in colorectal cancer using microarrays.
Explore future perspectives in this research field.

Main Methods:

Gene expression profiling analysis
Microarray technology

Main Results:

Microarrays enable simultaneous analysis of thousands of genes.
Gene expression patterns provide insights into tumor characteristics.

Conclusions:

Gene expression profiling with microarrays holds significant potential for colorectal cancer research.
This technology can aid in molecular classification and guide clinical management.