Related Experiment Video
Updated: Jun 27, 2026
Colorectal Cancer Cell Surface Protein Profiling Using an Antibody Microarray and Fluorescence Multiplexing
Published on: September 25, 2011
Gene expression profiling in colorectal cancer using microarray technologies: results and perspectives
Margherita Nannini1, Maria Abbondanza Pantaleo, Alessandra Maleddu
1Department of Hematology and Oncology sciences "L. A. Seragnoli", Sant'Orsola-Malpighi Hospital, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy.
Abstract:
Nowadays molecular biology represents one of the most interesting topics in medical oncology, because it provides a global and detailed view on the molecular changes involved in tumour progression, leading to a better understanding of the carcinogenesis process, to discovering new prognostic markers and novel therapeutic targets. The gene expression profiling analysis with microarray technology has shown a great potential in cancer research and in medical oncology, mapping simultaneously the expression of thousands of genes in a single tumour sample and giving a measurement of articulated genes expression patterns. Colorectal cancer represents a wide and exciting area of research for molecular biology, due to the growing need of a molecular classification as well as prognostic and predictive molecular factors that may guide oncologists in patient's clinical management. The aim of this review is to analyze the state of art of gene expression profile in colorectal cancer using microarrays technologies and to explore some perspectives in this research field.
Insights
Molecular biology and gene expression profiling using microarrays offer insights into colorectal cancer progression. This review examines current microarray applications and future directions for molecular classification and targeted therapies.
Area of Science:
- Molecular biology
- Medical oncology
- Cancer research
Background:
- Molecular biology provides a detailed view of tumor progression and carcinogenesis.
- Gene expression profiling with microarrays analyzes thousands of genes simultaneously.
- Colorectal cancer research needs molecular classification and prognostic/predictive factors.
Purpose of the Study:
- Review the current state of gene expression profiling in colorectal cancer using microarrays.
- Explore future perspectives in this research field.
Main Methods:
- Gene expression profiling analysis
- Microarray technology
Main Results:
- Microarrays enable simultaneous analysis of thousands of genes.
- Gene expression patterns provide insights into tumor characteristics.
Conclusions:
- Gene expression profiling with microarrays holds significant potential for colorectal cancer research.
- This technology can aid in molecular classification and guide clinical management.
More Related Videos
10:33Molecular Profiling of the Invasive Tumor Microenvironment in a 3-Dimensional Model of Colorectal Cancer Cells and Ex vivo Fibroblasts
Published on: April 29, 2014
10:59Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments
Published on: February 7, 2025
