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Updated: Jun 27, 2026

Using Three-color Single-molecule FRET to Study the Correlation of Protein Interactions
Published on: January 30, 2018
Graphical representation of proteins as four-color maps and their numerical characterization
Milan Randić1, Ketij Mehulić, Damir Vukicević
1National Institute of Chemistry, 1001 Ljubljana, Slovenia. mrandic@msn.com
Abstract:
We put forward a novel compact 2-D graphical representation of proteins based on the concept of virtual genetic code and a four-color map. The novel graphical representation uniquely represents proteins and allows one to easily and quickly visually observe and inspect similarity/dissimilarity between them. It also leads to a novel protein descriptor, a 10-dimensional vector derived from a novel structure matrix S associated with the map. The introduced numerical characterization of proteins is not only useful for their comparative study, but also for cataloguing information on a single protein. The approach is illustrated with the A chain of human insulin and the A chain of human insulin analogue glargine.
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