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Removal of FKBP12 enhances mTOR-Raptor interactions, LTP, memory, and perseverative/repetitive behavior

Charles A Hoeffer1, Wei Tang, Helen Wong

  • 1Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA.

Neuron
|December 17, 2008
PubMed
Summary

FKBP12 gene disruption enhances brain mTOR signaling, leading to improved synaptic plasticity and memory in mice. This suggests FKBP12 is crucial for regulating memory and related behaviors.

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