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Updated: Jun 27, 2026
Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
Published on: January 20, 2023
Recovery of cognitive function after traumatic brain injury: a multilevel modeling analysis of Canadian outcomes
Bruce K Christensen1, Brenda Colella, Elizabeth Inness
1Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.
Objective:
To ascertain patterns of cognitive recovery during the first year after traumatic brain injury (TBI). Specifically, differential recovery across cognitive domains was investigated.
Design:
Prospective, longitudinal, naturalistic, 1-year follow-up study.
Setting:
Large, urban inpatient neurorehabilitation program.
Participants:
Patients (N=75) with moderate to severe TBI.
Interventions:
Not applicable.
Main Outcome Measures:
Patients with TBI were followed over the course of 1 year, during which participants' neuropsychological status was repeatedly evaluated at 3 time points (2, 5, and 12 months postinjury).
Results:
Multilevel modeling results were consistent with previous research, demonstrating that recovery in the first year postinjury is asymptotic in nature, with more accelerated recovery occurring during the first 5 to 6 months. Importantly, results also suggest that recovery is not uniform across cognitive domains. From 2 to 5 months postinjury, steeper recovery curves were revealed for indices of memory, speeded executive function, verbal abstraction, and manual dexterity relative to untimed tests of executive function and word knowledge. Recovery trajectories did not significantly vary as a function of cognitive domain over the course of the last 5 to 12 months.
Conclusions:
These results are the first to explore trajectories of recovery directly as a function of multiple cognitive domains. They are expected to have implications for rehabilitative efforts as well as our understanding of the architecture of natural recovery after TBI.
