Aspernolides A and B, butenolides from a marine-derived fungus Aspergillus terreus
Rajesh R Parvatkar1, Celina D'Souza, Ashootosh Tripathi
1Bioorganic Chemistry Laboratory, National Institute of Oceanography, Council of Scientific and Industrial Research (CSIR), Dona Paula, Goa 403 004, India. parvatkar@gmail.com
Abstract:
Two aromatic butenolides, aspernolides A and B along with the known metabolites, butyrolactone I, terrein and physcion were isolated from the fermentation broth of a soft coral derived fungus Aspergillus terreus. The structures of these metabolites were assigned on the basis of detailed spectroscopic analysis. The absolute stereochemistry of aspernolides A (1) and B (2) was established by their preparation from the known butyrolactone I. Biogenetically aspernolides A and B must be derived from butyrolactone I, a well known specific inhibitor of cyclin dependent kinase (cdk) from A. terreus. When tested, aspernolide A exhibited mild cytotoxicity against cancer cell lines.
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