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Ceramicines B-D, new antiplasmodial limonoids from Chisocheton ceramicus
Khalit Mohamad1, Yusuke Hirasawa, Marc Litaudon
1Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa, Tokyo 142-8501, Japan.
Bioorganic & Medicinal Chemistry
|December 17, 2008
Summary
Three new compounds, ceramicines B-D, were identified from Chisocheton ceramicus bark. These novel limonoids show moderate activity against the malaria parasite Plasmodium.
Area of Science:
- Natural Product Chemistry
- Organic Chemistry
- Medicinal Chemistry
Background:
- Chisocheton ceramicus is a plant species known for potential bioactive compounds.
- Limonoids are a class of terpenoids with diverse biological activities.
Purpose of the Study:
- To isolate and characterize new limonoids from Chisocheton ceramicus.
- To evaluate the antiplasmodial activity of the isolated compounds.
Main Methods:
- Isolation of compounds from plant bark.
- Structure elucidation using 2D Nuclear Magnetic Resonance (NMR) analysis.
- Assessment of antiplasmodial activity.
Main Results:
- Three new limonoids, designated ceramicines B-D (compounds 1-3), were successfully isolated.
- The structures and stereochemistry of ceramicines B-D were fully determined.
- The isolated ceramicines demonstrated moderate antiplasmodial activity.
Conclusions:
- The bark of Chisocheton ceramicus is a source of novel limonoids.
- Ceramicines B-D represent new chemical entities with potential therapeutic applications.
- Further investigation into the antiplasmodial properties of ceramicines is warranted.
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