Synthesis of sulfone-based nucleotide isosteres: identification of CMP-sialic acid synthetase inhibitors
Jessica H Wong1, Urvashi Sahni, Yanhong Li
1Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, CA, USA.
Organic & Biomolecular Chemistry
|December 17, 2008
Abstract:
A modular replacement approach to the synthesis of sulfo-nucleotide analogs prepared from condensation of nucleoside aldehydes with bis phosphonate Horner-Wadsworth-Emmons reagents is disclosed. These analogs were shown to be inhibitors of Neisseria meningitidis CSS (NmCSS), which is a key enzyme in the biosynthesis of the capsular polysaccharides required for bacterial infection.
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