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Oral ofloxacin therapy for invasive external otitis
D Zikk1, Y Rapoport, C Redianu
1Department of Otorhinolaryngology, Tel Aviv Sourasky Medical Center, Ichilov Hospital, Israel.
The Annals of Otology, Rhinology, and Laryngology
|August 1, 1991
Summary
Oral ofloxacin effectively treated pseudomonal invasive external otitis (IEO) in adults, with an 83.3% cure rate. This convenient therapy showed minimal side effects, though some cases developed resistance or allergic reactions.
Area of Science:
- Infectious Diseases
- Otolaryngology
- Pharmacology
Background:
- Pseudomonal invasive external otitis (IEO) is a serious infection often affecting elderly patients with underlying conditions like diabetes mellitus.
- Pseudomonas aeruginosa is a common pathogen in IEO, necessitating effective antimicrobial treatment.
Purpose of the Study:
- To evaluate the clinical efficacy and safety of oral ofloxacin in treating pseudomonal IEO.
- To assess the outcomes in patients with mild versus severe forms of the disease.
Main Methods:
- A study involving 24 adult patients with pseudomonal IEO, divided into mild (Group A) and severe (Group B) forms.
- Patients received oral ofloxacin at 400 mg twice daily.
- Clinical outcomes, pathogen identification, and adverse events were monitored.
Main Results:
- An overall cure rate of 83.3% was achieved with oral ofloxacin treatment.
- Two patients required multiple treatment courses for cure.
- Three cases of P. aeruginosa resistance to ofloxacin and one severe allergic reaction led to treatment discontinuation.
- Minor side effects including nausea, arthralgia, and vaginal itching were reported.
Conclusions:
- Oral ofloxacin is an effective, convenient, safe, and economical treatment option for IEO caused by susceptible organisms.
- The study highlights the potential for ofloxacin resistance and allergic reactions, necessitating careful patient monitoring.
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