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Updated: Jun 27, 2026

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Published on: June 10, 2021
Synthesis of palladacycles employing iminoisoindolines as monoanionic bidentate ligands
Jackson M Chitanda1, Demyan E Prokopchuk, J Wilson Quail
1University of Saskatchewan, Department of Chemistry, 110 Science Place, S7N 5C9, Saskatoon, Saskatchewan, Canada.
Abstract:
A series of air- and moisture-stable iminoisoindoline-based palladacycles have been prepared in two operationally simple steps from commercially available reagents. para-Substituted N,N'-diphenyliminoisoindoline ligands are easily synthesized from phthalaldehyde and para-substituted anilines and further reaction of the iminoisoindoline ligands with Pd(OAc)(2) in dichloromethane at room temperature results in formation of six-membered [C,N] dinuclear cyclopalladated complexes with the general formula [(iminoisoindoline)Pd(micro-OAc)](2). The resulting palladacyclic complexes were tested as precatalysts in Heck and Suzuki coupling reactions.
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