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Updated: Jun 27, 2026

Analysis of Oxidative Stress in Zebrafish Embryos
Published on: July 7, 2014
[Oxidative stress: a review on metabolic signaling in type 1 diabetes]
Janice Sepúlveda Reis1, Clara Araújo Veloso, Rafael Teixeira Mattos
1Núcleo de Pesquisa e Pós-graduação, Santa Casa de Belo Horizonte, Belo Horizonte, MG. janicesepulveda@terra.com.br
Abstract:
Diabetic complications appear to be multifactorial process. The biochemical and pathological mechanisms are associated with chronic hyperglycemia of diabetes and the increased oxidative stress which has been postulated to play a central role in these disorders. Accumulating evidence suggests that oxidative cell injury caused by free radicals contributes to the development of type 1 diabetes (DM1) complications and decreased efficiency of antioxidant defenses (both enzymatic and nonenzymatic) seems to correlate with the severity of pathological tissue changes in DM1. In this review, we report as oxidative stress may exert deleterious effects in diabetes, as well as address current strategies in study to down-regulating vascular injury.
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