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Updated: Jun 27, 2026
Facial Nerve Surgery in the Rat Model to Study Axonal Inhibition and Regeneration
Published on: May 5, 2020
Influence of cyclic AMP on facial nerve regeneration in rats
Andrei Borin1, Ronaldo Nunes Toledo2, Paulo Lee Ho3
1Master's degree in otorhinolaryngology; doctoral student.
Unlabelled:
Promoting facial nerve regeneration is a significant challenge.
Aim:
To evaluate the possible neurotrophic influence of cyclic AMP on facial nerve regeneration of Wistar rats.
Method:
The right facial nerve of thirty-two animals were completely transected and immediately sutured, followed by exposure or not to topical cyclic AMP. Behavioral and histometric analyses were done at 14 and 28 days.
Results:
Statistical differences (p<0.05) were found in the behavioral and histometric analyses on the 14th day, suggesting an early regenerative response of the facial nerve to cAMP exposure.
Conclusion:
This study demonstrates a possible neurotrophic effect of cAMP on facial nerve regeneration in rats.
