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Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
Published on: July 16, 2017
Data deposition and annotation at the worldwide protein data bank
Shuchismita Dutta1, Kyle Burkhardt, Jasmine Young
1Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB), Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854-8087, USA.
Molecular Biotechnology
|December 17, 2008
Summary
The Protein Data Bank (PDB) provides free access to 3D biological macromolecular structures. It details the methods for data submission, processing, and release, aiding scientific discovery and education.
Area of Science:
- Structural biology
- Bioinformatics
- Molecular biology
Background:
- The Protein Data Bank (PDB) serves as a crucial global archive for experimentally determined three-dimensional structures of biological macromolecules.
- Accessibility of this structural data is vital for advancing scientific understanding and facilitating new discoveries.
Purpose of the Study:
- To describe the current tools and methodologies employed for data deposition, processing, and release within the PDB.
- To provide insights into the PDB's role in supporting scientific research, education, and public understanding of molecular biology.
Main Methods:
- Description of data deposition workflows.
- Explanation of data processing and validation techniques.
- Overview of data release protocols and archival management.
Main Results:
- The PDB offers readily available, free access to a vast repository of structural data via the internet.
- These structural data are instrumental for a diverse user base, including scientists, educators, and students.
- Analysis of PDB data drives innovation and new insights in molecular and biological sciences.
Conclusions:
- The PDB's robust data management system supports the scientific community by providing essential structural information.
- Continued development and enhancement of PDB tools and methods will further facilitate molecular-level understanding and scientific breakthroughs.
- The PDB is an indispensable resource for research, education, and public engagement with structural biology.
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