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Translesion DNA Polymerases02:10

Translesion DNA Polymerases

Translesion (TLS) polymerases rescue stalled DNA polymerases at sites of damaged bases by replacing the replicative polymerase and installing a nucleotide across the damaged site. Doing so, TLS allows additional time for the cell to repair the damage before resuming regular DNA replication.
TLS polymerases are found in all three domains of life - archaea, bacteria, and eukaryotes. Of the different classes of TLS polymerases, members of the Y family are fitted with specialized structures that...

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Related Experiment Video

Updated: Jun 27, 2026

Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
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Nucleoside Triphosphates - From Synthesis to Biochemical Characterization

Published on: April 3, 2014

Terminal deoxyribonucleotidyl transferase (EC 2.7.7.31)

F Grosse1, A Manns

  • 1Max-Planck-Institut fur Experimentelle Medizin, Abteilung Chemie, Gottingen, Germany.

Methods in Molecular Biology (Clifton, N.J.)
|December 17, 2008
PubMed
Summary

No abstract available in PubMed .

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