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Isolation and Culture of Primary Endothelial Cells from Canine Arteries and Veins

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Finding cardiovascular disease genes in the dog.

Heidi G Parker¹, Kathryn M Meurs, Elaine A Ostrander

¹National Human Genome Research Institute, National Institutes of Health, 50 South Drive, MSC 8000, Building 50, Room 5334, Bethesda, MD 20892-8000, USA.

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Summary

Recent canine genomics advances offer new diagnostic and therapeutic options for veterinarians. Genetic tools are improving the identification and screening of inherited diseases in dogs, enhancing companion animal healthcare.

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Area of Science:

Veterinary biology
Canine genetics
Comparative medicine

Background:

Canine genomics is rapidly evolving, transforming veterinary diagnostics and therapeutics.
Advances in canine genetics enable application of human and mouse genetic findings to companion animals.
The availability of a dense genome map and whole genome sequence facilitates genetic research.

Purpose of the Study:

To review recent findings in canine genomics.
To discuss the application of canine genomics to canine cardiac health.
To highlight the impact of genomics on veterinary medicine.

Main Methods:

Review of recent literature on canine genomics.
Analysis of the impact of genome mapping and sequencing.
Discussion of genetic screening tools and their cost-effectiveness.

Main Results:

Canine genome mapping aids comparative medicine.
Whole genome sequencing accelerates identification of hereditary disease genes.
Genetic tools will decrease costs for disease locus identification and testing.

Conclusions:

Genomic advances are revolutionizing veterinary diagnostics and therapy.
Veterinarians will offer genetic testing and counseling for various canine disorders.
Canine genomics holds significant promise for improving companion animal health, particularly cardiac health.