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Cardioprotective actions of grape polyphenols
Wayne R Leifert1, Mahinda Y Abeywardena
1Commonwealth Scientific and Industrial Research Organisation, Division of Human Nutrition, PO Box 10041, Adelaide BC, SA 5000, Australia. wayne.leifert@csiro.au
Grape polyphenols from extracts and products like red wine show significant antioxidant and cardioprotective effects. Evidence suggests these compounds may help prevent inflammatory diseases, particularly cardiovascular disease.
Area of Science:
- Cardiovascular Research
- Nutritional Science
- Pharmacology
Background:
- Grape extracts contain polyphenols like resveratrol, anthocyanins, and flavonoids.
- These compounds exhibit potent antioxidant properties.
- Grape-derived polyphenols are implicated in preventing inflammatory diseases.
Purpose of the Study:
- To review evidence on grape polyphenols' biological actions.
- To discuss their role in preventing inflammatory diseases, especially cardiovascular disease.
- To highlight cardioprotective and vasoprotective properties.
Main Methods:
- Literature review of accumulating evidence.
- Identification of active components in grape extracts (seed, skin, juice).
- Analysis of biological actions and mechanisms of action.
Main Results:
- Grape polyphenols decrease LDL-cholesterol oxidation and platelet aggregation.
- Compounds demonstrate antiatherosclerotic, antiarrhythmic, and vasorelaxation effects.
- Antioxidant properties are central to their mechanism, alongside signaling and genomic interactions.
Conclusions:
- Grape extracts rich in polyphenols show promise for cardiovascular disease prevention.
- Consumption of grape products may benefit chronic degenerative disease prevention.
- Further evidence supports the role of grape polyphenols in health.
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