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Updated: Jan 4, 2026

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
Published on: January 15, 2022
Inflammatory aortitis with coronary arterial involvement by multidetector cardiac computed tomography.
Jo Mahenthiran1, Hicham El Masry, Shawn D Teague
1Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA. jmahenth@iupui.edu
This case highlights aortic inflammation as an unusual cause of myocardial infarction. Multidetector coronary computed tomography (MDCCT) imaging aided in diagnosing this rare condition.
Area of Science:
- Cardiology
- Radiology
- Inflammatory Diseases
Background:
- Myocardial infarction typically arises from coronary artery atherosclerosis.
- Aortic inflammation is an uncommon etiology for myocardial ischemia.
Observation:
- A 40-year-old hypertensive male presented with non-ST-segment myocardial infarction.
- Multidetector coronary computed tomography (MDCCT) revealed aortic intramural thickening and extrinsic compression of the left circumflex coronary artery.
Findings:
- Positron emission tomography confirmed active inflammation in the proximal aorta and coronary arteries.
- The findings suggest aortic inflammation as the cause of myocardial ischemia.
Implications:
- This case underscores the importance of considering uncommon causes of myocardial ischemia.
- MDCCT demonstrates a valuable role in diagnosing inflammatory aortic and coronary artery diseases.
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