Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Healthcare Associated Infections II: Preventive Measures

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...

Standard Precaution

Standard Precaution

Standard precautions are the minimum infection control safeguards used while caring for all patients, irrespective of their disease condition. They help prevent the spread of common infectious microorganisms to healthcare workers, patients, and visitors in all healthcare settings.
Hand hygiene is the most crucial means to prevent the transmission of disease. Employers are legally required to provide their workers with personal protective equipment (PPE) to minimize exposure or contact with...

Endocarditis IV: Nursing Management

Endocarditis IV: Nursing Management

Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...

Cleaning, Sterilization, and Disinfection

Cleaning, Sterilization, and Disinfection

Cleaning, disinfection, and sterilization are the methods that help to break the infection chain and prevent disease.
Cleaning
The cleaning process usually involves using water with detergents or enzymatic cleaner and removing foreign material from objects and surfaces, including organic material such as body fluids or inorganic material like soil. Cleaning is performed before high-level disinfection and sterilization because foreign materials on the cover of the devices interfere with process...

Clinical Significance of Antibiotic Resistance

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...

Endocarditis III: Medical Management

Endocarditis III: Medical Management

Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Multimodal Analgesia for Acute Pain.

The American journal of nursing·2017

Same author

Consensus conference on prevention of central line-associated bloodstream infections: 2009.

Journal of infusion nursing : the official publication of the Infusion Nurses Society·2011

Same author

Use of hypochlorite solution to decrease rates of Clostridium difficile-associated diarrhea.

Infection control and hospital epidemiology·2007

Same author

Routine screening for methicillin-resistant Staphylococcus aureus among patients newly admitted to an acute rehabilitation unit.

Infection control and hospital epidemiology·2002

Search research articles

Related Experiment Video

Updated: Jun 27, 2026

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit

Published on: July 13, 2019

Zeroing in on zero tolerance for central line-associated bacteremia.

¹Missouri Baptist Medical Center, St. Louis, MO, USA. Jez3285@bjc.org

American Journal of Infection Control

|December 17, 2008

Summary

This summary is machine-generated.

Implementing educational interventions and a "scrub the hub" bundle significantly reduced central line-associated bacteremia (CLAB) rates in intensive care units (ICUs). These strategies fostered a zero-tolerance infection culture, improving patient outcomes.

More Related Videos

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Related Experiment Videos

Last Updated: Jun 27, 2026

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit

Published on: July 13, 2019

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Area of Science:

Healthcare-associated infections
Infection control
Patient safety

Background:

Central line-associated bacteremia (CLAB) significantly increases intensive care unit (ICU) length of stay, hospital length of stay, mortality, and costs.
In 1999, the CLAB rate at Barnes Jewish Hospital (BJH) surgical-burn-trauma ICU was 10.8/1000 central venous catheter (CVC) line-days, exceeding national rates.

Purpose of the Study:

To evaluate the effectiveness of an educational intervention and specific bundles in reducing CLAB rates within ICUs.
To promote a culture of zero tolerance for infections in critical care settings.

Main Methods:

A multidisciplinary team developed an educational intervention including self-study modules with pre- and posttests.
Focus-PDCA methodology was used to chart practices, leading to the development of informational tools and a "scrub the hub" bundle.
Nurses at Missouri Baptist Medical Center (MBMC) completed the educational module and implemented the "scrub the hub" bundle.

Main Results:

At BJH, the CLAB rate decreased from 10.8 to 3.7/1000 CVC line-days (P < .01) post-intervention, further reducing to 2.8/1000 CVC line-days with additional tools.
At MBMC, ICUs achieved prolonged periods with no CLAB (334 and 212 days).
Following the educational module and "scrub the hub" bundle implementation at MBMC, one ICU had no CLAB for 61 days, and the other had only one case.

Conclusions:

The educational intervention, informational tools, and "scrub the hub" bundle were effective in reducing CLAB rates in ICUs.
These interventions contributed to establishing a culture of zero tolerance for infection within critical care settings.