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Related Experiment Video

Updated: Jun 27, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

[Juvenile pemphigus vulgaris].

D Janisson-Dargaud¹, Z Reguiaï, G Perceau

¹Service de dermatologie, hôpital Robert-Debré, CHU de Reims, avenue Général-Koenig, 51100 Reims, France. ddargaud@hotmail.fr

Annales De Dermatologie Et De Venereologie

|December 17, 2008

Summary

This summary is machine-generated.

Juvenile pemphigus vulgaris is a rare autoimmune disease. Rituximab offers a promising treatment for severe pediatric cases resistant to conventional therapies like corticosteroids.

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Last Updated: Jun 27, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid

Published on: June 17, 2025

Area of Science:

Immunodermatology
Pediatric Autoimmune Diseases

Background:

Pemphigus vulgaris is a rare autoimmune blistering disease.
Juvenile pemphigus vulgaris is exceptionally rare in children.
Diagnosis relies on histology and immunopathology.

Observation:

Two pediatric patients presented with oral and/or cutaneous blisters.
Histology confirmed suprabasal acantholysis.
Immunofluorescence identified characteristic antibody targets.

Findings:

One patient, refractory to corticosteroids and IVIG, responded well to rituximab.
Rituximab treatment for juvenile pemphigus vulgaris is sparsely reported.
This case adds to the limited evidence of rituximab efficacy in pediatric cases.

Implications:

Atypical presentations of juvenile pemphigus vulgaris can delay diagnosis.
Rituximab may be a viable option for recalcitrant pediatric pemphigus vulgaris.
Further research is needed to establish rituximab's role in juvenile cases.