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Updated: Jun 24, 2026

An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells
Published on: September 12, 2019
[Lymphoma-like lesions of the endometrium]
Lucie Gaillot1, Fabienne Allias, Gil Dubernard
1Service d'anatomie et cytologie pathologiques des hôpitaux Nord, centre de biologie et pathologie Nord, hôpital de la Croix-Rousse, 103 Grande-Rue de la Croix-Rousse, 69317 Lyon cedex 04, France.
Abstract:
Chronic endometritis is a rare entity characterized by an endometrial plasmocytic infiltrate. The lymphoid infiltrate may be abundant and simulate a lymphoma of the uterus. We report two cases of lymphoma-like lesions of the endometrium in two postmenopausal women of 79 and 89 year-old, who presented with abundant vaginal discharge. Ultrasound examination revealed in both cases an intrauterin polypoid lesion. Histologically, a predominantly plasmocytic infiltrate was seen in the endometrium destroying endometrial glandes and extending into the superficial myometrium, in the first case. Immunohistochemical study showed a polymorphic lymphoid infiltrate with a predominance of Tcells. Molecular study revealed a polyclonalB cell population, distinguishing the lesion from a marginal zone lymphoma. Lymphoma-like lesions of female genital tract must be distinguished from malignant lymphoma that rarely occurs in this site.
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