Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

CBF measured by Xe-CT: approach to analysis and normal values.

H Yonas1, J M Darby, E C Marks

  • 1Department of Neurosurgery, University of Pittsburgh School of Medicine, Pennsylvania.

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
|September 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The role of ECMO support in airway procedures.

BJA education·2023
Same author

Causes and diagnostic utility of musculoskeletal MRI recall examinations.

Clinical radiology·2022
Same author

On the ecophysiology of the Clusiaceae in Trinidad: expression of CAM in Clusia minor L. during the transition from wet to dry season and characterization of three endemic species.

The New phytologist·2021
Same author

Oxytocin at elective caesarean delivery: a dose-finding study in women with obesity.

Anaesthesia·2020
Same author

Pregnancy and COVID-19: pharmacologic considerations.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2020
Same author

Neonatal outcome by planned mode of delivery in women with a body mass index of 35 or more: a retrospective cohort study.

BJOG : an international journal of obstetrics and gynaecology·2020
Same journal

EXPRESS: Therapeutic Hypothermia Via Hypothalamic Neuromodulation: A New Approach for Stroke Brain Protection.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same journal

EXPRESS: Endothelial estrogen receptor alpha (ESR1) regulates cerebral cavernous malformation pathogenesis via MEKK3-KLF signalling pathway.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same journal

EXPRESS: The Role and Mechanism of Lysyl Hydroxylase 1 (LH1) in Vascular Lesions in Hypertensive Intracerebral Hemorrhage.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same journal

Brain barriers as checkpoints in endocrine regulation of body homeostasis.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same journal

Ferroptosis of microvascular pericytes contributes to ischemia-reperfusion injury in mice.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same journal

EXPRESS: Post-Ischemic Sodium Glucose Cotransporter Inhibition Attenuates Ischemia-Reperfusion Injury via Regulation of Mitochondrial Membrane Potential.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
See all related articles

This study establishes normal reference values for cerebral blood flow (CBF) using xenon-enhanced CT (Xe-CT). It provides a practical method for analyzing CBF, noting age-related declines in high-flow areas.

Area of Science:

  • Neurology
  • Radiology
  • Medical Imaging

Background:

  • Routine clinical analysis of cerebral blood flow (CBF) requires established normal reference values.
  • Xenon-enhanced computed tomography (Xe-CT) is a valuable tool for CBF imaging, but interpretation can be challenging without normative data.

Purpose of the Study:

  • To establish normal reference values for CBF using Xe-CT.
  • To develop a practical and uncomplicated method for analyzing Xe-CT CBF studies.

Main Methods:

  • CBF was measured in 67 normal individuals using a GE 9800 CT scanner with stable xenon.
  • Vascular territories were analyzed using clustered regions of interest (ROIs) in cortical and subcortical areas.
  • High and low flow compartments were sampled using 5-mm ROIs.

Related Experiment Videos

Main Results:

  • Mixed cortical flows averaged 51 ± 10 ml/100g/min.
  • High flow compartments averaged 84 ± 14 ml/100g/min, and low flow compartments averaged 20 ± 5 ml/100g/min.
  • Significant age-related declines were observed in mixed cortical and high flow compartments, but not in low flow compartments.

Conclusions:

  • The study provides a normative database for Xe-CT CBF analysis.
  • A flexible and uncomplicated method for analyzing CBF maps generated by Xe-CT has been developed.
  • These findings aid in the routine clinical interpretation of Xe-CT CBF studies.