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Corpora amylacea in the peripheral nerve axons
Acta Neuropathologica
|January 31, 1977
Summary
Electron microscopy revealed glycogen-related filamentous deposits within peripheral nerve axons in familial spastic paralysis. These findings offer new insights into the ultrastructural pathology of this neurological disorder.
Area of Science:
- Neuropathology
- Neuroscience
- Cell Biology
Background:
- Familial spastic paralysis (FSP) is a group of inherited neurological disorders.
- Peripheral nerve involvement in FSP is not fully understood.
- Corpora amylacea-like deposits have been observed in the central nervous system.
Purpose of the Study:
- To investigate the ultrastructural characteristics of deposits found in peripheral nerves of an FSP patient.
- To explore the relationship between these deposits and cellular components like glycogen.
Main Methods:
- Electron microscopy was used to examine peripheral nerve biopsies.
- Ultrastructural analysis focused on the morphology and composition of observed inclusions.
Main Results:
- Deposits resembling corpora amylacea were identified within myelinated axons.
- These deposits were composed of randomly interlacing short filaments.
- Filaments showed a close association with peripheral glycogen granules.
Conclusions:
- The filamentous structures may be related to glycogen metabolism or storage.
- These findings contribute to understanding the cellular pathology in familial spastic paralysis.
- Further research is needed to elucidate the exact nature and significance of these inclusions.