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Related Experiment Video

Updated: Jun 27, 2026

A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies
09:32

A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies

Published on: September 23, 2014

Tissue array for Tp53, C-myc, CCND1 gene over-expression in different tumors.

Guo-Yan Liu1, Qi Luo, Bin Xiong

  • 1Department of General Surgery, Affiliated Zhongshan Hospital of Xiamen University, Xiamen 361004, Fujian Province, China.

World Journal of Gastroenterology
|December 17, 2008
PubMed
Summary
This summary is machine-generated.

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

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This study investigated the role of Tp53, C-myc, and CCND1 genes in human cancer development. Over-expression of these genes is significantly correlated with various carcinomas, suggesting their involvement in tumor progression.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cancer development involves complex molecular alterations.
  • Specific genes like Tp53, C-myc, and CCND1 are implicated in tumorigenesis.
  • Understanding gene expression in different tumor types is crucial for diagnosis and treatment.

Purpose of the Study:

  • To detect molecular alterations in various malignancies.
  • To investigate the role of Tp53, C-myc, and CCND1 genes in human cancer.
  • To explore the relationship between gene expression and tumor differentiation.

Main Methods:

  • Generated a tissue array of seven different human tumors.
  • Utilized RNA in situ hybridization to determine gene expression levels.
  • Employed specific oligonucleotide and locked nucleic acid probes for detection.

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Multiomics Analysis of TMEM200A as a Pan-Cancer Biomarker

Published on: September 15, 2023

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Last Updated: Jun 27, 2026

A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies
09:32

A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies

Published on: September 23, 2014

Multiomics Analysis of TMEM200A as a Pan-Cancer Biomarker
07:47

Multiomics Analysis of TMEM200A as a Pan-Cancer Biomarker

Published on: September 15, 2023

Main Results:

  • Tp53 gene expression was elevated in most carcinoma tissues compared to normal tissues.
  • CCND1 gene expression showed significant differences across various carcinoma types.
  • C-myc gene expression varied significantly in esophagus, stomach, and thyroid carcinomas.

Conclusions:

  • Over-expression of Tp53, CCND1, and C-myc genes is linked to human cancer development.
  • These genes play a significant role in the progression of various carcinomas.
  • Gene expression regulation is a key factor in tumorigenesis.