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Basicity of Heterocyclic Aromatic Amines

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Source and Route of Pyrrolizidine Alkaloid Contamination in Tea Samples

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A pyrrole derivative from Paeonia suffruticosa.

K Xiao¹, Q-H Song, S-W Zhang

¹State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

Natural Product Research

|December 17, 2008

Summary

A novel pyrrole derivative, paesuffrioside, was isolated from Paeonia suffruticosa root. This study details its structure and identifies two other compounds new to this plant species.

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Area of Science:

Phytochemistry
Natural Product Chemistry
Pharmacognosy

Background:

Paeonia suffruticosa (tree peony) is a valuable medicinal plant.
Its root cortex is a source of bioactive compounds.
Understanding its chemical constituents is crucial for its medicinal applications.

Purpose of the Study:

To isolate and characterize novel compounds from Paeonia suffruticosa root cortex.
To identify known compounds present in the water-soluble extract.
To elucidate the structures of isolated compounds using advanced analytical techniques.

Main Methods:

Water-soluble extraction of Paeonia suffruticosa root cortex.
Isolation of compounds using chromatographic techniques.
Structure elucidation via spectroscopic analysis (NMR, MS) and chemical transformation.
Identification of known compounds through comparison with literature data.

Main Results:

A new pyrrole derivative, paesuffrioside (2-methyl-5-(2'-O-alpha-D-glucopyranosyl-1'-oxygen)-propylpyrrole) (1), was isolated and characterized.
Eleven known compounds were also isolated from the extract.
Two known compounds (2 and 3) were reported from this plant for the first time.

Conclusions:

The chemical investigation of Paeonia suffruticosa root cortex yielded a new pyrrole derivative, paesuffrioside.
The study expanded the known phytochemical profile of Paeonia suffruticosa.
This research contributes to the understanding of the chemical diversity of Paeonia species.