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Related Concept Videos

Quality Control01:05

Quality Control

Quality control is one of the three cyclical quality assurance activities that help keep a system under statistical control. Typical quality control activities include creating quality control charts, conducting proficiency testing, and documenting and archiving results.
Quality control helps track data, visualize trends, and identify variations, making it easier to detect deviations that may affect the accuracy of an analysis. One way to do this is by generating a quality control chart, which...
Quality Assurance01:19

Quality Assurance

Quality assurance is the overarching term used to describe the activities employed to ensure the proper performance of a system. These activities can be classified into three categories: quality control, quality assessment, and internal corrective measures. Typically, these activities work cyclically: quality control is performed before and during the analysis, while quality assessment occurs during and after the investigation. Internal corrective measures are implemented based on the findings...
Coagulation01:06

Coagulation

Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
Coagulation01:09

Coagulation

The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
Data Validation01:15

Data Validation

Method validation is a crucial process in analytical chemistry designed to confirm that a given method consistently produces reliable and high-quality results. This process is essential when a method is applied to different sample matrices or when procedural modifications are made, ensuring that the results meet acceptable standards across various applications.
Key parameters for method validation include:
Controlled-Current Coulometry: Overview01:27

Controlled-Current Coulometry: Overview

Controlled current coulometry, also known as amperostatic coulometry, is a technique used in electrochemical analysis to measure the quantity of a substance through the controlled passage of current. It involves the application of a constant current to an electrochemical cell containing the analyte of interest. As the current flows through the cell, the analyte undergoes a redox reaction at the electrode surface, resulting in a charge transfer. By monitoring the time required for a certain...

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The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well
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Quality control in coagulation testing.

Mario Plebani1, Maria Colomba Sanzari, Lorena Zardo

  • 1Department of Laboratory Medicine, University-Hospital of Padova, Italy. mario.plebani@unipd.it

Seminars in Thrombosis and Hemostasis
|December 17, 2008
PubMed
Summary
This summary is machine-generated.

Quality control in laboratory medicine, including internal quality control (IQC) and external quality assessment (EQA), is vital for accurate hemostasis testing. Evidence shows current coagulation testing quality is often unsatisfactory, necessitating improved performance goals.

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Area of Science:

  • Laboratory Medicine
  • Hemostasis and Thrombosis
  • Clinical Diagnostics

Background:

  • Quality control (QC) encompasses procedures for monitoring laboratory testing performance, detecting errors, and ensuring accurate results.
  • Internal quality control (IQC) and external quality assessment (EQA) are key components for evaluating and enhancing laboratory medicine quality.
  • Accurate laboratory testing is crucial for diagnosing and managing hemostatic disorders.

Purpose of the Study:

  • To review the current state of quality control and assessment in hemostasis testing.
  • To highlight the limitations in scientific evidence compared to other laboratory medicine fields.
  • To identify the need for improved performance goals and address new challenges in quality assessment.

Main Methods:

  • Review of existing scientific literature on quality control and assessment in laboratory medicine, with a focus on hemostasis.
  • Analysis of current data on analytical quality in coagulation testing.
  • Identification of emerging challenges in external quality assessment schemes.

Main Results:

  • While QC/QA benefits in hemostasis are recognized, scientific evidence is less extensive than in clinical chemistry.
  • Available data indicates that the analytical quality of coagulation testing is frequently unsatisfactory.
  • There is a clear need for more objective performance goals to guide IQC and EQA programs.

Conclusions:

  • The quality of hemostasis testing requires significant improvement, supported by a growing body of evidence.
  • Establishing objective performance goals is essential for optimizing both internal quality control and external quality assessment.
  • Future quality assessment schemes must adapt to innovative tests, genetic analysis, and the entire testing process.