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Related Experiment Video

Updated: Jun 27, 2026

Generation of Lymphocytic Microparticles and Detection of their Proapoptotic Effect on Airway Epithelial Cells

Generation of Lymphocytic Microparticles and Detection of their Proapoptotic Effect on Airway Epithelial Cells

Published on: February 20, 2015

Microparticles in health and disease.

Anoop K Enjeti¹, Lisa F Lincz, Michael Seldon

¹Department of Haematology level 4, Hunter Haematology Research Group, New Medical Building, Calvary Mater Hospital, Waratah Newcastle, Australia. Anoop.Enjeti@mater.health.nsw.gov.au

Seminars in Thrombosis and Hemostasis

|December 17, 2008

Summary

Microparticles (MPs), cell membrane fragments, are increasingly recognized for intercellular communication. Elevated circulating MPs are linked to thrombosis and cancer, prompting investigation into their biomarker potential.

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Isolation and Characterization of Neutrophil-derived Microparticles for Functional Studies

Isolation and Characterization of Neutrophil-derived Microparticles for Functional Studies

Published on: March 2, 2018

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Generation of Lymphocytic Microparticles and Detection of their Proapoptotic Effect on Airway Epithelial Cells

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Isolation and Characterization of Neutrophil-derived Microparticles for Functional Studies

Isolation and Characterization of Neutrophil-derived Microparticles for Functional Studies

Published on: March 2, 2018

Area of Science:

Cell Biology
Biochemistry
Pathophysiology

Background:

Microparticles (MPs) are membrane-bound cytoplasmic fragments released from activated or apoptotic cells.
MPs mediate intercellular communication, transferring biological information between cells.
Circulating MP levels reflect cellular health, proliferation, and death dynamics.

Purpose of the Study:

To explore the mechanisms of MP production and their role in intercellular communication.
To investigate the clinical significance of elevated MPs in various diseases.
To assess the potential of MPs as diagnostic and prognostic biomarkers.

Main Methods:

The study discusses the complex biophysical and biochemical mechanisms of MP formation, including cytoskeletal changes and phospholipid asymmetry.
It reviews clinical conditions associated with elevated MP levels.
The text highlights the ongoing research into MP detection and measurement methodologies.

Main Results:

MP production involves intricate interplay of proteins regulating cell membrane remodeling, cytoskeletal dynamics, and phospholipid transport.
Elevated circulating MPs are observed in cardiovascular diseases, venous thromboembolism, and metastatic solid tumors.
These elevated levels are frequently associated with prothrombotic states.

Conclusions:

MPs represent a significant pathway for intercellular communication with implications in various pathologies.
The association of elevated MPs with thrombosis and cancer suggests their potential as clinical biomarkers.
Further research and clinical trials are essential to validate MP measurement for routine diagnostic and prognostic use.