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Related Experiment Video

Updated: Jun 27, 2026

Intravitreous Injection for Establishing Ocular Diseases Model
05:37

Intravitreous Injection for Establishing Ocular Diseases Model

Published on: October 1, 2007

[Globe explosion due to intravitreal injection].

A Viestenz1, M Küchle, W Behrens-Baumann

  • 1Univ.-Augenklinik, Otto-von-Guericke-Universität, Magdeburg. arne.viestenz@med.ovgu.de

Klinische Monatsblatter Fur Augenheilkunde
|December 17, 2008
PubMed
Summary

Intravitreal triamcinolone acetonide injections can lead to severe complications like globe explosion. Risk factors include nanophthalmos and scleral weakness, suggesting prophylactic measures for high-risk patients.

Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Ocular Surgery

Background:

  • Age-related maculopathy is a common cause of vision loss.
  • Intravitreal injections are a standard treatment for wet age-related maculopathy.
  • Triamcinolone acetonide (TA) is frequently used for its anti-inflammatory and anti-angiogenic properties.

Observation:

  • A severe complication occurred during an intravitreal TA injection in an 83-year-old female.
  • Globe explosion with nasal limbal rupture and extrusion of intraocular contents was observed.
  • Surgical findings included a 9 mm limbal rupture, iris prolapse, and lens extrusion.

Findings:

  • The patient had risk factors including relative nanophthalmos, scleral weakness from chemotherapy, advanced age, and a large TA injection volume.

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Last Updated: Jun 27, 2026

Intravitreous Injection for Establishing Ocular Diseases Model
05:37

Intravitreous Injection for Establishing Ocular Diseases Model

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An Alternative and Validated Injection Method for Accessing the Subretinal Space via a Transcleral Posterior Approach
07:13

An Alternative and Validated Injection Method for Accessing the Subretinal Space via a Transcleral Posterior Approach

Published on: December 7, 2016

  • Despite the severe complication, the patient retained her preoperative visual acuity of counting fingers.
  • Emergency wound repair, lens removal, anterior vitrectomy, and iris repositioning were performed.

    • Implications:

    • Intravitreal injections, while beneficial, carry risks of serious ocular complications.
    • Pre-injection paracentesis or limited pars plana vitrectomy may mitigate risks in high-risk individuals.
    • Careful patient selection and risk assessment are crucial for intravitreal drug delivery.