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Related Concept Videos

Sutures of the Skull01:22

Sutures of the Skull

The human skull is composed of several bones that come together to protect the brain and support the structures of the face. The junctions where these bones meet are called sutures.
Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...

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Related Experiment Video

Updated: Jun 27, 2026

Closure of a Patent Foramen Ovale (PFO): An Intervention Sequence
10:52

Closure of a Patent Foramen Ovale (PFO): An Intervention Sequence

Published on: December 23, 2022

A suture not always the ideal solution: problems encountered in developing a suture-based PFO closure technique.

Nicolas Majunke1, Andreas Baranowski, Wibke Zimmermann

  • 1CardioVascular Center Frankfurt, Frankfurt, Germany.

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
|December 17, 2008
PubMed
Summary
This summary is machine-generated.

A novel suture-based technique for patent foramen ovale (PFO) closure is safe and feasible. However, this method did not achieve complete PFO closure in most patients during follow-up.

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Polytetrafluoroethylene (PTFE) as a Suture Material in Tendon Surgery
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Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Structural Heart Disease

Background:

  • Patent foramen ovale (PFO) is associated with cryptogenic stroke and migraine with aura.
  • Percutaneous catheter techniques with various closure devices are established for PFO closure.
  • A novel suture-based system aims for PFO closure via endovascular delivery of a suture.

Purpose of the Study:

  • To evaluate the initial clinical experience and outcomes of a first-in-man suture-based PFO closure technique.
  • To assess the safety and efficacy of this novel transcatheter approach.

Main Methods:

  • Eleven patients (22-58 years) with cryptogenic stroke, TIA, or peripheral embolism and PFO underwent closure with the suture technique.
  • Balloon sizing determined the mean defect diameter (8.8 mm).
  • Suture delivery was attempted in all patients with subsequent follow-up.

Main Results:

  • Suture delivery was technically successful in all 11 patients with no intraprocedural complications.
  • Complete PFO closure was achieved in only one patient.
  • Six patients with significant residual shunting required closure with conventional devices; three had minimal shunting and declined further treatment.

Conclusions:

  • Transcatheter suture application for PFO closure is technically feasible and safe.
  • Despite successful suturing, the novel technique failed to achieve complete PFO closure in the majority of patients.
  • Further refinement or alternative strategies may be needed for effective suture-based PFO closure.