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Hepatitis delta virus inhibits alpha interferon signaling.

Paolo Pugnale1, Valerio Pazienza, Kévin Guilloux

  • 1Division of Clinical Pathology, University Hospital, Geneva, Switzerland.

Hepatology (Baltimore, Md.)
|December 17, 2008
PubMed
Summary

Hepatitis delta virus (HDV) impairs interferon-alpha (IFN-alpha) treatment effectiveness by blocking the JAK-STAT pathway. This viral interference prevents antiviral gene expression and STAT1/STAT2 activation, contributing to treatment resistance in chronic hepatitis delta.

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