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Related Experiment Video

Updated: Jun 27, 2026

Ex Utero Electroporation and Organotypic Slice Cultures of Embryonic Mouse Brains for Live-Imaging of Migrating GABAergic Interneurons
09:50

Ex Utero Electroporation and Organotypic Slice Cultures of Embryonic Mouse Brains for Live-Imaging of Migrating GABAergic Interneurons

Published on: April 20, 2018

Relationship between GABAergic interneurons migration and early neocortical network activity.

Ana D de Lima1, Anne Gieseler, Thomas Voigt

  • 1Developmental Physiology, Institute of Physiology, Otto-von-Guericke University, 39120 Magdeburg, Germany.

Developmental Neurobiology
|December 17, 2008
PubMed
Summary

Early network activity in the developing brain appears to regulate neuronal migration. Specifically, neurotransmitters from network activity may signal the end of migration for GABAergic neurons.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • Spontaneous network activity emerges during early cerebral cortex development, overlapping with the end of neuronal cell migration.
  • Understanding the interplay between neuronal migration and network activity is crucial for comprehending cortical development.

Purpose of the Study:

  • To investigate the functional regulation of neuronal migration by network activity in a neocortical culture model.
  • To explore the relationship between cell migration dynamics and the onset of synchronous network activity.

Main Methods:

  • Utilized time-lapse microscopy to track neuronal migratory movements.
  • Employed calcium imaging to assess the activity of migrating neurons.
  • Applied immunocytochemical methods for retrospective identification of migratory cells.

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Migratory Behavior of Cells Generated in Ganglionic Eminence Cultures
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Migratory Behavior of Cells Generated in Ganglionic Eminence Cultures

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Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains
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Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains

Published on: June 8, 2018

Related Experiment Videos

Last Updated: Jun 27, 2026

Ex Utero Electroporation and Organotypic Slice Cultures of Embryonic Mouse Brains for Live-Imaging of Migrating GABAergic Interneurons
09:50

Ex Utero Electroporation and Organotypic Slice Cultures of Embryonic Mouse Brains for Live-Imaging of Migrating GABAergic Interneurons

Published on: April 20, 2018

Migratory Behavior of Cells Generated in Ganglionic Eminence Cultures
06:34

Migratory Behavior of Cells Generated in Ganglionic Eminence Cultures

Published on: April 21, 2011

Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains
10:08

Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains

Published on: June 8, 2018

Main Results:

  • Neuronal migration persisted until at least 12 days in vitro, with GABAergic neurons migrating faster than non-GABAergic neurons.
  • A decrease in migratory activity coincided with the emergence of spontaneous, synchronous network activity.
  • Newly settled interneurons rapidly engaged in synchronous network activity, while migrating interneurons did not.

Conclusions:

  • Neurotransmitter release from early network activity may promote the termination of neuronal migration.
  • Network activity plays a significant role in the developmental maturation of late-born GABAergic cells.