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Myoclonus of peripheral origin: two case reports.

Louise Tyvaert¹, Pierre Krystkowiak, Francois Cassim

¹Department of Neurology and Movement Disorders, Lille University Hospital, Lille Cedex, France.

Movement Disorders : Official Journal of the Movement Disorder Society

|December 17, 2008

Summary

This summary is machine-generated.

Peripheral myoclonus, a movement disorder following nerve injury, is demonstrated in two cases. Localized nerve treatments effectively resolved symptoms, suggesting a peripheral origin for this condition.

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Area of Science:

Neurology
Movement Disorders
Nerve Injury

Background:

Peripheral myoclonus is often difficult to diagnose due to unclear causality between trauma and movement disorders.
Establishing a clear link between peripheral nerve injury and subsequent myoclonus remains a challenge in clinical practice.

Observation:

Two cases of peripheral myoclonus following nerve injury are presented.
Case 1: Myoclonus in the 4th dorsal interosseous muscle after elbow trauma.
Case 2: Arm stump myoclonus and phantom-limb pain post-amputation, with normal central nervous system findings.

Findings:

Central nervous system imaging and electrophysiological tests were normal in both patients.
Local anesthetic and botulinum toxin injections in the second patient's stump rapidly alleviated myoclonus and pain.
Nerve injury can lead to ephaptic transmission and ectopic excitation, contributing to myoclonus.

Implications:

These findings support the hypothesis of a peripheral generator causing myoclonus.
Peripheral myoclonus, though not widely accepted, can result from nerve trauma.
Understanding peripheral mechanisms may lead to targeted treatments for movement disorders post-nerve injury.