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Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...
Yellow Fever01:18

Yellow Fever

Yellow fever is a viral hemorrhagic disease caused by the yellow fever virus (YFV), a member of the Flaviviridae family. It is transmitted primarily by Aedes and Haemagogus mosquitoes in tropical and subtropical regions of Africa and South America. After transmission through a mosquito bite, the virus initially replicates in skin-resident immune cells such as dendritic cells and macrophages. These cells then migrate to the lymph nodes, where viral replication increases, eventually leading to...

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Related Experiment Video

Updated: Jun 27, 2026

"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection
10:25

"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection

Published on: February 19, 2019

[Markers of hepatitis virus].

Fumitaka Suzuki1

  • 1Department of Hepatology, Toranomon Hospital, Tokyo 105-8470, Japan. fumitakas@toranomon.gr.jp

Rinsho Byori. the Japanese Journal of Clinical Pathology
|December 18, 2008
PubMed
Summary

New methods for detecting Hepatitis B virus (HBV) and Hepatitis C virus (HCV) DNA/RNA offer improved sensitivity and quantitation, enhancing therapy monitoring and management for viral hepatitis patients.

Area of Science:

  • Virology
  • Hepatology
  • Infectious Diseases

Context:

  • Hepatitis B virus (HBV) and hepatitis C virus (HCV) are primary causes of viral hepatitis.
  • Serological markers are crucial for diagnosing and determining the prognosis of HBV/HCV infections.
  • Detecting HBV DNA in serum is vital for predicting outcomes in chronic HBV infection.

Purpose:

  • To evaluate new methods for detecting HBV and HCV viral load.
  • To assess the sensitivity and quantitation range of novel viral detection techniques.
  • To explore advancements in viral hepatitis diagnosis and treatment monitoring.

Summary:

  • Conventional methods for detecting HBV DNA and HCV RNA have limitations in sensitivity and detection range.
  • The Cobas Taq Man HCV Test demonstrates enhanced sensitivity and a broader quantitation range for HBV DNA and HCV RNA.

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Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA

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Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle
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Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle

Published on: February 1, 2017

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Last Updated: Jun 27, 2026

"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection
10:25

"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection

Published on: February 19, 2019

Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA
04:11

Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA

Published on: December 15, 2023

Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle
09:35

Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle

Published on: February 1, 2017

  • New methods improve therapy monitoring and management of HBV and HCV infections.
  • Hepatitis E virus (HEV) and its markers are also discussed.

    • Impact:

    • Improved diagnostic accuracy for viral hepatitis.
    • Enhanced monitoring of treatment response in HBV and HCV patients.
    • Potential for better patient management and outcomes in viral hepatitis care.