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[Antioxidant xanthones from Securidaca inappendiculata].

Wen-yi Kang1, Cai-fang Li, Yan-li Song

  • 1Institute of Natural Products, Henan University, Kaifeng 475004, China. kangweny@hotmail.com

Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica
|December 18, 2008
PubMed
Summary
This summary is machine-generated.

Two new xanthones were identified from Securidaca inappendiculata roots, alongside seven known compounds. Aucuparin and compound 1 demonstrated significant antioxidant activity in various assays.

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Area of Science:

  • Phytochemistry
  • Natural Products Chemistry
  • Pharmacognosy

Context:

  • Securidaca inappendiculata is a plant species with potential medicinal properties.
  • Investigating plant-derived compounds for therapeutic applications is crucial for drug discovery.
  • Antioxidants play a vital role in combating oxidative stress-related diseases.

Purpose:

  • To isolate and characterize antioxidant constituents from the roots of Securidaca inappendiculata.
  • To evaluate the antioxidant potential of the isolated compounds using established assays.

Summary:

  • Bioassay-guided fractionation using column chromatography led to the isolation of two new xanthones (1 and 2) and seven known xanthones.
  • Structural elucidation was performed using spectroscopic methods including IR, MS, NMR, and 2D-NMR.
  • Compounds 1 and 2 are novel xanthones, while compound 3 is reported as a natural product for the first time, and compounds 4 and 6 are new to the genus.

Impact:

  • Compound 9 (aucuparin) and compound 1 exhibited significant antioxidant activity in ABTS, FRAP, and DPPH assays.
  • Compound 1 showed a potent DPPH radical scavenging activity with an IC50 value of 0.31 mg/L.
  • The study contributes to the understanding of the phytochemical profile of Securidaca inappendiculata and its potential as a source of antioxidants.