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Updated: Jun 27, 2026
High-resolution Tandem Mass Spectrometry for Studying Chemical Constituents of Gynura bicolor DC
Published on: February 2, 2024
[Studies on bioactive constituents of whole herbs of Vernonia cinerea]
Hua-xu Zhu1, Yu-ping Tang, Lin-mei Pan
1School of life sciences, Nanjing Normal University, Nanjing 210024, China. Huaxu72@yahoo.com.cn
Objective:
To study the constituents of the whole herbs of Vernonia cinerea. by bio-activity guided isolation with PC-12 model.
Method:
The constituents were separated by column chromatography and the structures were elucidated by spectroscopic methods.
Result:
Four compounds were identified to be (+)-lirioresinol B (1), stigmasterol (2), stigmasterol-3-O-beta-D-glucoside (3), 4-sulfo-benzocyclobutene (4), and their NGF inducing activity were also investigated.
Conclusion:
Compounds 1, 3, 4 were isolated from this genus for the first time, and compound 4 was identified as a new natural product. Compounds 1, 3, 4 showed cytotoxicity on PC-12, and compounds 2, 3, 4 showed inhibition activity. Compound 4 showed a specific effect on the survival of TrkA fibroblasts, and resulted in the inducing NGF activity.